South Carolina Vacation Rentals Discover the best short term rentals South Carolina has to offer: from beach bungalows to luxury homes. All of South CarolinaCharleston Isle of Palms Edisto Island Folly Beach James Island Kiawah Island Johns Island Seabrook Island People 1+ 2+ 3+ 4+ 5+ 6+ 7+ 8+ 9+ 10+ 11+ 12+ USA > South Carolina Visit South Carolina Welcome to South Carolina, where Southern charm and breathtaking landscapes await you! Immerse yourself in the warm hospitality of the region as you explore historic cities, pristine beaches, and lush forests. Discover rich American history while strolling through picturesque streets lined with vibrant art and mouthwatering cuisine. Whether you’re seeking a relaxing getaway or thrilling adventures, South Carolina offers the perfect blend of relaxation and excitement. Come experience the genuine smiles and easygoing vibes that make this state a true gem in the heart of the South. Pack your bags and let the magic of South Carolina embrace you! Favorite South Carolina Destinations Edisto Island, SCIsle of Palms, SCCharleston, SCKiawah, SCFolly Beach, SCSeabrook, SC Find Your South Carolina Rental Seaside Hideaway Johns Island, SC 4 Guests 1 Bdrm 2 Baths From $375/night incl. feesnext avail Nov 17–19 · 2-night min Featured Property Oyster Rake Oasis Kiawah Island, South Carolina 8 Guests 3 Bdrms 2 Baths From $508/night incl. feesnext avail Nov 7–9 · 2-night min Harry's on the Beach Johns Island, South Carolina 2 Guests 1 Bdrm 1 Bath From $405/night incl. feesnext avail Apr 2–5, 2027 · 3-night min Featured Property Paradise Palms with Private Pool Isle of Palms, SC 10 Guests 5 Bdrms 5 Baths From $687/night incl. feesnext avail Nov 12–15 · 3-night min Featured Property Family Beachhouse with Oceanview - Gone Coastal Isle of Palms, SC 12 Guests 6 Bdrms 6 Baths From $1,058/night incl. feesnext avail Nov 15–17 · 2-night min Maggie's Oceanfront Getaway Folly Beach, SC 6 Guests 3 Bdrms 1 Bath From $454/night incl. feesnext avail Nov 9–11 · 2-night min Featured Property Toosie's Tide Seabrook Island, SC 8 Guests 3 Bdrms 2 Baths From $486/night incl. feesnext avail Nov 7–9 · 2-night min Drift Away Cottage Kiawah Island, SC 7 Guests 3 Bdrms 2 Baths From $621/night incl. feesnext avail Nov 7–10 · 3-night min 211 Sea Cabin 1Br1Ba Pool and Pier Isle of Palms, SC 4 Guests 1 Bdrm 1 Bath From $293/night incl. feesnext avail Nov 17–18 Folly Waterfront Condo - Pool, Screened Porch Folly Beach, SC 8 Guests 3 Bdrms 3 Baths From $451/night incl. feesnext avail Nov 7–9 · 2-night min Once Upon A Tide Folly Beach, SC 6 Guests 2 Bdrms 1 Bath From $290/night incl. feesnext avail Nov 28 – Dec 2 · 4-night min Featured Property 140C Sea Cabin in the heart of IOP! 1BR1BA Pool and Pier Isle of Palms, SC 4 Guests 1 Bdrm 1 Bath From $277/night incl. feesnext avail Nov 9–10 Search while moving Featured South Carolina Vacation Rentals Featured Property Oyster Rake Oasis Kiawah Island, South Carolina 8 Guests 3 Bdrms 2 Baths From $508/night incl. feesnext avail Nov 7–9 · 2-night min Featured Property Paradise Palms with Private Pool Isle of Palms, SC 10 Guests 5 Bdrms 5 Baths From $687/night incl. feesnext avail Nov 12–15 · 3-night min Featured Property Family Beachhouse with Oceanview - Gone Coastal Isle of Palms, SC 12 Guests 6 Bdrms 6 Baths From $1,058/night incl. feesnext avail Nov 15–17 · 2-night min Featured Property Toosie's Tide Seabrook Island, SC 8 Guests 3 Bdrms 2 Baths From $486/night incl. feesnext avail Nov 7–9 · 2-night min Featured Property 140C Sea Cabin in the heart of IOP! 1BR1BA Pool and Pier Isle of Palms, SC 4 Guests 1 Bdrm 1 Bath From $277/night incl. feesnext avail Nov 9–10 Featured Property Sand Dollar Beach House with Private Pool/Hot Tub Isle of Palms, SC 12 Guests 5 Bdrms 5 Baths From $2,246/night incl. feesnext avail Jun 5–12, 2027 · 7-night min Featured Property Saltbox Isle Of Palms, SC 12 Guests 4 Bdrms 4 Baths From $1,337/night incl. feesnext avail Nov 7–14 · 7-night min Featured Property Songbird Cottage - 12 Atlantic Beach Kiawah Island, SC 12 Guests 5 Bdrms 5 Baths From $1,505/night incl. feesnext avail Jun 5–12, 2027 · 7-night min Property Management You Can Trust Owning a vacation rental shouldn’t be stressful. Let SkyRun ease your worries and increase your revenue with our vacation rental management solutions. Why choose SkyRun? As locally owned businesses, our homeowners are not just a number to us, they’re our neighbors. But as a franchise, we have access to tools and tech that help you stay ahead of the game. That’s why thousands of second homeowners trust us with their properties. Learn More Matt was very clear from the start and helped us build real expectations for our investment property. We’re pleased with how easy the process has been. Paul & ClaireBradenton, FL If you are looking for the best full service vacation rental property management, stop searching and call SkyRun. They have systems and processes in place to ensure the highest possible short term rental revenue and guests love them! We couldn’t be happier with their management of our homes. TheodoreScottsdale, Arizona Sign up for emails Trip inspiration, special offers, and vacation planning tips. 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